What is Alpha-lipoic Acid?

Alpha-lipoic acid, is a sulfur-containing fatty acid is found inside every cell of the body, where it helps generate the energy that keeps us alive and functioning. Alpha-lipoic acid is a key part of the metabolic pathway that turns glucose (blood sugar) into energy.

Alpha-lipoic acid is being recognized for its great value as an antioxidant, which means it neutralizes naturally occurring, but harmful, chemicals known as free radicals. Alpha-lipoic acid is relatively unique because it works in both the aqueous (water soluble) and lipid (fat soluble) phases of the body.

One of the more interesting findings about alpha-lipoic acid is that it may help regenerate other antioxidants that have been used up. Some research also suggests that lipoic acid may do the work of other antioxidants in which the body is deficient.

Natural sources for Alpha-lipoic Acid:

The body generally makes enough alpha-lipoic acid to supply it's needs; however, certain conditions such as diabetes, liver cirrhosis, and heart disease are accompanied by low levels of alpha-lipoic acid, and supplementation may be helpful. Liver and yeast contain some alpha-lipoic acid.

Alpha-lipoic Acid is useful in treating:

Diabetic Neuropathy: Alpha-lipoic acid has been widely used in Germany to treat the nerve damage caused by diabetes, called diabetic neuropathy. Symptoms include numbness, pain, and burning, mostly in the hands and feet (so-called "stocking and glove" distribution). There is clear evidence that it has benefit intravenously, and some studies also show a benefit with the oral form also.

Glucose control in Diabetes: There are some studies suggesting that diabetic control may be improved with alpha-lipoic acid, but the evidence is mixed.

Liver disease: One small study has shown benefit for alpha-lipoic acid as part of a combination "triple antioxidant" therapy for hepatitis C with liver failure.

Lead toxicity: Alpha-lipoic acid seems to be a good candidate for therapeutic intervention of lead poisoning, in combination with a chelator.

Recommended dosage for Alpha-lipoic Acid:

As a general antioxidant, 50 mg per day is generally considered sufficient. For treatment of diabetic neuropathy or for liver disease, 300 mg twice daily is an appropriate dose.

Important Alpha-lipoic Acid Note:

It is generally thought to be without side effects. Safety in pregnant and lactacting women, as well as children has not been established.

 

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